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Al-Azhar University – Gaza
2021
Acta Pharmaceutica Sciencia
Flavonoids from plant source as protein tyrosine phosphatase 1b inhibitors: In silico update
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Istanbul Medipol University
Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmacy, Al Azhar University-Gaza, Gaza Strip, Palestine; Department of Biological Sciences, University of Jordan, Amman, Jordan; Hamdi Mango Center for Scientific Research, The University of Jordan, Amman, Jordan; Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, 27272, United Arab Emirates
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10.23893/1307-2080.APS.05939
antidiabetic agent; catechin; chalcone; chalcone derivative; flavonoid; glucose transporter 4; isoflavone; isorhamnetin; leptin; luteolin; mammalian target of rapamycin complex 2; natural product; orientin; piceatannol; protein kinase; protein kinase B; protein tyrosine phosphatase; protein tyrosine phosphatase 1B; protein tyrosine phosphatase 1B inhibitor; quercetin; Article; autophosphorylation; binding affinity; body weight loss; computer aided design; computer model; crystal structure; cyclization; drug design; enzyme activity; enzyme inhibition; enzyme kinetics; glucose homeostasis; glucose transport; glycosylation; hydrogen bond; hydrophobicity; IC50; immune response; insulin resistance; molecular docking; molecular model; pharmacophore; protein expression; protein phosphorylation; protein protein interaction; signal transduction