Determination of levetiracetam enantiomeric purity using hplc-fluorescence detection coupled with a pre-column o-phthalaldehyde-n-acetyl-l-cysteine derivatization

field_of_study

Blank

university

Al-Azhar University – Gaza

authors

Ramadan M.

authors_full_names

Ramadan, Mai (55781889100)

authors_id

55781889100

year

2021

source_title

Journal of Research in Pharmacy

article_title

Determination of levetiracetam enantiomeric purity using hplc-fluorescence detection coupled with a pre-column o-phthalaldehyde-n-acetyl-l-cysteine derivatization

volume

25

issue

5

page_start

738

page_end

746

publisher

Marmara University

affiliations

Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmacy, Al-Azhar University-Gaza, Gaza, Palestine

authors_with_affiliations

Ramadan M., Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmacy, Al-Azhar University-Gaza, Gaza, Palestine

corresponding_author

M. Ramadan; Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmacy, Al-Azhar University-Gaza, Gaza, Palestine; email: m.ramadan@alazhar.edu.ps

cited_by

1

doi

10.29228/jrp.64

author_keywords

Fluorescence; HPLC; Levetiracetam; N-acetyl-L-cysteine; O-phthalaldehyde; R-enantiomer; Validation

index_keywords

acetylcysteine; ammonium acetate; boric acid; isoindole derivative; levetiracetam; methanol; phthalaldehyde; Article; chemical structure; derivatization; enantiomer; enantioseparation; flow rate; fluorescence; high performance liquid chromatography; limit of detection; limit of quantitation; pH; quality control; racemic mixture